Alkaline phosphatase originates from many tissues in the body. When alkaline phosphatase is increased in the bloodstream of a dog, the most common causes are liver disease, bone disease, or increased blood cortisol from specific drugs or because the animal has Cushing's disease (hyperadrenocorticism).. High cholesterol does not predispose.. Alkaline phosphatase is a group of enzymes in the body that cause the breakdown of organic compounds in the body called phosphate esters. This enzyme is produced by two specific genes or isoenzymes: Intestinal ALP gene/isoenzyme. Tissue non-specific ALP gene/isoenzyme. Each isoenzyme has a different amino acid sequence but has similar enzymatic.
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Alkaline phosphatase (ALP)
By Admin October 11, 2023. Elevated Alkaline Phosphatase (ALP) levels in dogs can be a cause for concern among pet owners. ALP is an enzyme found in various tissues of the body, including the liver, bones, and intestines. When the levels of ALP in a dog's blood are higher than normal, it may indicate an underlying health issue.. Veterinary internists are often asked to consult about middle aged to older dogs that have moderately elevated serum levels of alkaline phosphatase (ALK, ALP, SAP), a commonly measured liver enzyme. If pets appear otherwise well, it is exceedingly important to verify the abnormal result before pursuing it as a potential problem.
